An internal standard for the quantification of methimazole
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Unlabeled Version(s)
23718Methimazole
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Methimazole-d3

Item No. 33278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-(methyl-d3)-2H-imidazole-2-thione
CAS Number
1160932-07-9
Molecular Formula
C4H3D3N2S
Formula Weight
117.2
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
S=C1NC=CN1C([2H])([2H])[2H]
InChi Code
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)/i1D3
InChi Key
PMRYVIKBURPHAH-FIBGUPNXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $134

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    1 mg

    $213

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    Product Description

    Methimazole-d3 is intended for use as an internal standard for the quantification of methimazole (Item No. 23718) by GC- or LC-MS. Methimazole is an inhibitor of thyroid hormone synthesis.1,2 It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat.4 Methimazole has been used to induce hypothyroidism in mice.5,6 Formulations containing methimazole have been used in the treatment of hyperthyroidism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davidson, B., Soodak, M., Neary, J.T., et al. The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazole, thiouracil, and propylthiouracil in vitro and its relationship to in vivo findings. Endocrinology 103(3), 871-872 (1978).

    2. Cooper, D.S. Antithyroid drugs. N. Engl. J. Med. 352(9), 905-917 (2005).

    3. Brock, R.E., and Head, W.F., Jr. Mechanisms of antithyroidal activity of methimazole. J. Pharm. Sci. 55(8), 822-825 (1966).

    4. Allen, E.M., Rajatanavin, R., Nogimori, T., et al. The effect of methimazole on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W rat. Am. J. Med. Sci. 292(5), 267-271 (1986).

    5. Bortolotto, V.C., Pinheiro, F.C., Araujo, S.M., et al. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. Eur. J. Pharmacol. 822, 78-84 (2018).

    6. Bortolotto, V.C., Araujo, S.M., Pinheiro, F.C., et al. Modulation of glutamate levels and Na+,K+-ATPase activity contributes to the chrysin memory recovery in hypothyroidism mice. Physiol. Behav. 222, 112892 (2020).