An internal standard for the quantification of oxaprozin
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Unlabeled Version(s)
15476Oxaprozin
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Oxaprozin-d5

Item No. 33279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-phenyl-5-(phenyl-d5)-2-oxazolepropanoic acid
CAS Number
2933758-40-6
Molecular Formula
C18H10D5NO3
Formula Weight
298.4
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
OC(CCC1=NC(C2=CC=CC=C2)=C(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])O1)=O
InChi Code
InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)/i2D,5D,6D,9D,10D
InChi Key
OFPXSFXSNFPTHF-OUHXUHDZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $117

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    1 mg

    $218

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    Product Description

    Oxaprozin-d5 is intended for use as an internal standard for the quantification of oxaprozin (Item No. 15476) by GC- or LC-MS. Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 μM for human COX-1 and COX-2, respectively).1 It decreases acetic acid-induced writhing times and carrageenan-induced paw edema in mice when administered at doses of 100 and 70 mg/kg, respectively.2 Formulations containing oxaprozin have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawai, S., Nishida, S., Kato, M., et al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur. J. Pharmacol. 347(1), 87-94 (1998).

    2. Zhou, X.P., Zhang, M.X., Sun, W., et al. Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug. Biol. Pharm. Bull. 32(12), 1986-1990 (2009).