An NMDA receptor antagonist
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Arcaine (sulfate)

Item No. 33284

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′′′-1,4-butanediylbis-guanidine, monosulfate
CAS Number
14923-17-2
Molecular Formula
C6H16N6 • H2SO4
Formula Weight
270.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
O=S(O)(O)=O.N=C(NCCCCNC(N)=N)N
InChi Code
InChI=1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
InChi Key
RWTGFMPOODRXIM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

    $95

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    100 mg

    $169

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    Product Description

    Arcaine is an antagonist of the NMDA receptor (IC50 = 9.13 µM).1 It inhibits NMDA and glycine-induced inward currents in X. laevis oocytes expressing rat NMDA receptors with an IC50 value of 60.1 µM.2 Arcaine impairs contextual and auditory fear conditioning in rats when administered intraperitoneally post-training at a dose of 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharma, T.A., Carr, A.J., Davis, R.S., et al. Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. Bioorg. Med. Chem. Lett. 8(24), 3459-3464 (1998).

    2. Maciver, C.R., Bednar, D.L., and Karbon, E.L. Opposite effects of spermine and arcaine on responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Neurosci. Lett. 132(2), 146-150 (1991).

    3. Camera, K., Mello, C.F., Ceretta, A.P.C., et al. Systemic administration of polyaminergic agents modulate fear conditioning in rats. Psychopharmacology (Berl) 192(4), 457-464 (2007).