A cell-impermeable metal chelating agent
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DTPA

Item No. 33307

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-glycine
CAS Number
67-43-6
Synonyms
  • Diethylenetriaminepentaacetic Acid
  • NSC 7340
  • Pentetic Acid
Molecular Formula
C14H23N3O10
Formula Weight
393.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly solubleMethanol: Slightly solublePBS (pH 7.2): Slightly soluble
SMILES
O=C(CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)O
InChi Code
InChI=1S/C14H23N3O10/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27)
InChi Key
QPCDCPDFJACHGM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $41

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    50 g

    $72

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    100 g

    $127

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    250 g

    $215

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    Cayman Chemical
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    Product Description

    DTPA is a cell-impermeable metal chelating agent.1,2 It chelates copper, iron, zinc, and manganese, as well as calcium, magnesium, and plutonium.1,3 DTPA has been used as a metal chelating agent in the study of ferroptosis.4 It reduces the skeletal plutonium burden and incidence of bone tumors, as well as increases survival in a mouse model of intravenous plutonium exposure when administered at a dose of 500 mg/kg.3 Formulations containing DTPA conjugated to radioactive compounds have been used as diagnostic agents for brain imaging, renal visualization, and lung imaging.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arts, J., Bade, S., Badrinas, M., et al. Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant? Regul. Toxicol. Pharmacol. 97, 197-208 (2018).

    2. Killilea, D.W., Atamna, H., Liao, C., et al. Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid. Redox Signal. 5(5), 507-516 (2003).

    3. Osenthal, M.W., and Lindenbaum, A. Influence of DTPA therapy on long-term effects of retained monomeric plutonium: Comparison with polymeric plutonium. Radiat. Res. 31(3), 506-521 (1967).

    4. Wenzel, S.E., Tyurina, Y.Y., Zhao, J., et al. PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell 171(3), 628-641 (2017).