The racemate of L-malic acid
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Product Categories

Product Type

Biochemicals

Research Area

Immunology & Inflammation
Innate Immunity

DL-Malic Acid

Item No. 33310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-butanedioic acid
CAS Number
6915-15-7
Synonyms
  • E 296
  • Hydroxybutanedioic Acid
  • (±)-Malic Acid
  • NSC 25941
  • 2-hydroxy Succinic acid
Molecular Formula
C4H6O5
Formula Weight
134.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(CC(C(O)=O)O)O
InChi Code
InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)
InChi Key
BJEPYKJPYRNKOW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    DL-Malic acid is the racemate of the metabolic intermediate L-malic acid.1 It reduces CCL2 and ICAM expression induced by IFN-γ and TNF-α in HaCaT human keratinocytes when used at a concentration of 1 mM.2 Topical administration of DL-malic acid (10 mM) inhibits epidermis and dermis thickening, as well as mast cell and eosinophil dermal infiltration in a mouse model of atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNBC). Formulations containing DL-malic acid have been used as food and cosmetic preservatives and acidity regulators.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryan, D.G., Murphy, M.P., Frezza, C., et al. Coupling Krebs cycle metabolites to signalling in immunity and cancer. Nat. Metab. 1, 16-33 (2019).

    2. Lee, B., Heo, J., Hong, S., et al. ᴅʟ-Malic acid as a component of α-hydroxy acids: Effect on 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in vitro and in vivo. Immunopharmacol. Immunotoxicol. 41(6), 614-621 (2019).