An iron chelator and derivative of desferrithiocin
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Product Categories

Product Type

Biochemicals
Metal Chelators

Research Area

Cancer

Deferitrin

Item No. 33328

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid
CAS Number
239101-33-8
Synonyms
  • GT-56-252
  • (S)-4'-Hydroxydesazadesferrithiocin
Molecular Formula
C11H11NO4S
Formula Weight
253.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 12 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.2 mg/ml
λmax
214, 231, 274, 309 nm
SMILES
OC1=C(C2=N[C@](C(O)=O)(C)CS2)C=CC(O)=C1
InChi Code
InChI=1S/C11H11NO4S/c1-11(10(15)16)5-17-9(12-11)7-3-2-6(13)4-8(7)14/h2-4,13-14H,5H2,1H3,(H,15,16)/t11-/m1/s1
InChi Key
OEUUFNIKLCFNLN-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

    $1,060

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    Product Description

    Deferitrin is an iron chelator and a derivative of desferrithiocin that binds iron in a 2:1 (ligand:iron) ratio.1,2 It inhibits the proliferation of L1210 murine leukemia cells (IC50 = 17 µM).3 Deferitrin (150 µmol/kg) induces iron excretion in iron-overloaded C. apella monkeys and beagle dogs with an iron clearing efficiency (ICE) of 14.5 and 9.3%, respectively.2 It reduces fecal and urine iron levels by 607 and 357 µg/kg in C. apella monkeys and beagle dogs, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bergeron, R.J., Wiegand, J., Bharti, N., et al. Desferrithiocin analogue iron chelators: Iron clearing efficiency, tissue distribution, and renal toxicity. Biometals 24(2), 239-258 (2011).

    2. Bergeron, R.J., Wiegand, J., Weimar, W.R., et al. Comparison of iron chelator efficacy in iron-overloaded beagle dogs and monkeys (Cebus apella). Comp. Med. 54(6), 664-672 (2004).

    3. Bergeron, R.J., Wiegand, J., Weimar, W.R., et al. Iron chelation promoted by desazadesferrithiocin analogs: An enantioselective barrier. Chirality 15(7), 593-599 (2003).