An iron chelator
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Deferitazole

Item No. 33329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4S,5-dihydro-2-[2-hydroxy-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid
CAS Number
945635-15-4
Synonyms
  • FBS0701
  • SPD-602
Molecular Formula
C18H25NO7S
Formula Weight
399.5
Purity
≥95%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
OC([C@]1(C)N=C(C2=CC=CC(OCCOCCOCCOC)=C2O)SC1)=O
InChi Code
InChI=1S/C18H25NO7S/c1-18(17(21)22)12-27-16(19-18)13-4-3-5-14(15(13)20)26-11-10-25-9-8-24-7-6-23-2/h3-5,20H,6-12H2,1-2H3,(H,21,22)/t18-/m1/s1
InChi Key
AWHIMFSHNAAMBM-GOSISDBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $87

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    5 mg

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    10 mg

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    25 mg

    $1,087

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    Cayman Chemical
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    Product Description

    Deferitazole is an iron chelator.1 It decreases the levels of iron in iron-citrate complexes when used at a concentration of 50 µM. Deferitazole (25 µM) also reduces the number of P. falciparum oocytes, an effect that can be prevented by the addition of ferric chloride, and the percent of flagellated P. falciparum male gametocytes in vitro.2 It decreases the urine and fecal levels of iron excreted from iron-loaded C. apella monkeys when administered at a dose of 150 µmol/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hider, R.C., Kong, X., Abbate, V., et al. Deferitazole, a new orally active iron chelator. Dalton Trans. 44(11), 5197-5204 (2015).

    2. Ferrer, P., Vega-Rodriguez, J., Tripathi, A.K., et al. Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition. Antimicrob. Agents Chemother. 59(3), 1418-1426 (2015).

    3. Bergeron, R.J., Wiegand, J., McManis, J.S., et al. Design, synthesis, and testing of non-nephrotoxic desazadesferrithiocin polyether analogues. J. Med. Chem. 51(13), 3913-3923 (2008).