A 20S proteasome activator
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Nifenazone

Item No. 33330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-pyridinecarboxamide
CAS Number
2139-47-1
Synonyms
  • Niapyrin
  • Nicotinoylantipyrine
Molecular Formula
C17H16N4O2
Formula Weight
308.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
272 nm
SMILES
O=C(C1=CC=CN=C1)NC2=C(C)N(C)N(C3=CC=CC=C3)C2=O
InChi Code
InChI=1S/C17H16N4O2/c1-12-15(19-16(22)13-7-6-10-18-11-13)17(23)21(20(12)2)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,19,22)
InChi Key
BRZANEXCSZCZCI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $134

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    100 mg

    $253

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    250 mg

    $598

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    500 mg

    $1,058

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    Product Description

    Nifenazone is an activator of the 20S proteasome.1 It activates the chymotryptic-like peptidase activity of the yeast 20S proteasome in a cell-free assay when used at a concentration of 0.5 µM. Nifenazone (50 µM) reduces decreases in mitochondrial activity and cell death induced by amyloid β (1-42) (Aβ42) in neuronally differentiated SH-SY5Y cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Santoro, A.M., Lanza, V., Bellia, F., et al. Pyrazolones activate the proteasome by gating mechanisms and protect neuronal cells from β-amyloid toxicity. ChemMedChem 15(3), 302-316 (2020).