An adenosine A1 receptor agonist
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INNO-8875

Item No. 33345

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclopentyl-adenosine, 5′-nitrate
CAS Number
871108-05-3
Synonyms
  • PJ 875
  • Trabodenoson
Molecular Formula
C15H20N6O6
Formula Weight
380.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
268 nm
SMILES
O[C@H]1[C@](O[C@@H]([C@H]1O)CO[N+]([O-])=O)([H])N2C3=NC=NC(NC4CCCC4)=C3N=C2
InChi Code
InChI=1S/C15H20N6O6/c22-11-9(5-26-21(24)25)27-15(12(11)23)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,22-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1
InChi Key
AQLVRTWKJDTWQQ-SDBHATRESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $167

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    10 mg

    $274

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    Product Description

    INNO-8875 is an adenosine A1 receptor agonist.1,2 It binds to adenosine A1 receptors (Ki = 0.97 nM) and is greater than 10,000-fold selective for adenosine A1 over A2 receptors. Topical application of INNO-8875 (25 µg/eye) reduces intraocular pressure in a rabbit model of ocular hypertension.2 INNO-8875 (1-50 µg/kg) decreases atrial refractoriness and heart rate, as well as slows atrioventricular nodal conduction, in anesthetized rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mor, M., Shalev, A., Dror, S., et al. INO-8875, a highly selective A1 adenosine receptor agonist: Evaluation of chronotropic, dromotropic, and hemodynamic effects in rats. J. Pharmacol. Exp. Ther. 344(1), 59-67 (2012).

    2. Kim, N., Crosson, C., Supuran, C., et al. INO-8875, an adenosine A1 agonist, in development for open-angle glaucoma reduces IOP in three rabbit models. Invert. Ophthalmol. Vis. Sci. 50(13), 4061 (2009).