A CaSR agonist
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Evocalcet

Item No. 33346

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(3S)-3-[[(1R)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]-benzeneacetic acid
CAS Number
870964-67-3
Synonyms
  • KHK7580
  • MT-4580
Molecular Formula
C24H26N2O2
Formula Weight
374.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
224 nm
SMILES
C[C@H](C1=CC=CC2=C1C=CC=C2)N[C@@H]3CN(C4=CC=C(CC(O)=O)C=C4)CC3
InChi Code
InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1
InChi Key
RZNUIYPHQFXBAN-XLIONFOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

    $427

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    25 mg

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    Product Description

    Evocalcet is an agonist of the calcium-sensing receptor (CaSR).1 It induces intracellular calcium release in HEK293 cells expressing human CaSR (EC50 = 92.7 nM). Evocalcet reduces serum levels of parathyroid hormone (PTH) and calcium when administered at doses of 0.3 and 0.1 mg/kg, respectively, in non-nephrectomized and 5/6 nephrectomized rats. It also reduces serum levels of PTH without inducing emesis in marmosets when administered at doses of 0.3 and 0.5 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawata, T., Tokunaga, S., Murai, M., et al. A novel calcimimetic agent, evocalcet (MT4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro. PLoS One 13(4), e0195316 (2018).