A SARS-CoV and SARS-CoV-2 PLpro inhibitor
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GRL-0617

Item No. 33348

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-benzamide
CAS Number
1093070-16-6
Molecular Formula
C20H20N2O
Formula Weight
304.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
λmax
224 nm
SMILES
O=C(C1=C(C=CC(N)=C1)C)N[C@@H](C2=CC=CC3=C2C=CC=C3)C
InChi Code
InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1
InChi Key
UVERBUNNCOKGNZ-CQSZACIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $98

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    10 mg

    $176

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    25 mg

    $392

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    Cayman Chemical
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    Product Description

    GRL-0617 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 papain-like proteases (PLpros; IC50s = 0.6 and 1.5 µM, respectively).1,2 It increases the viability of SARS-CoV-infected Vero E6 cells (EC50 = 14.5 µM).1 GRL-0617 (6.25-50 µM) reduces viral replication in SARS-CoV-2-infected Caco-2 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ratia, K., Pegan, S., Takayama, J., et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc. Natl. Acad. Sci. USA 105(42), 16119-16124 (2008).

    2. Shin, D., Mukherjee, R., Grewe, D., et al. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587(7835), 657-662 (2020).