A β3-AR agonist
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Vibegron

Item No. 33386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6,7,8-tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4 oxo-pyrrolo[1,2-a]pyrimidine-6-carboxamide
CAS Number
1190389-15-1
Synonyms
  • MK-4618
Molecular Formula
C26H28N4O3
Formula Weight
444.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O[C@H](C1=CC=CC=C1)[C@](CC2)([H])N[C@@H]2CC(C=C3)=CC=C3NC([C@H]4N5C(CC4)=NC=CC5=O)=O
InChi Code
InChI=1S/C26H28N4O3/c31-24-14-15-27-23-13-12-22(30(23)24)26(33)29-19-8-6-17(7-9-19)16-20-10-11-21(28-20)25(32)18-4-2-1-3-5-18/h1-9,14-15,20-22,25,28,32H,10-13,16H2,(H,29,33)/t20-,21+,22-,25+/m0/s1
InChi Key
DJXRIQMCROIRCZ-XOEOCAAJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 mg

    $35

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    500 mg

    $56

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    1 g

    $84

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    Product Description

    Vibegron is an agonist of the β3-adrenergic receptor (β3-AR).1 It selectively induces cAMP accumulation in cells expressing β3-ARs (EC50 = 2 nM) over β1- or β2-ARs for which it has no activity at 10 µM. Vibegron (3 mg/kg, i.v.) increases the micturition interval and decreases the micturition pressure in a female rat model of Parkinson’s disease with lower urinary tract (LUT) dysfunction.2 It reduces non-voiding contractions during bladder filling in mice with spinal cord injury.3 Formulations containing vibegron have been used in the treatment of overactive bladder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brucker, B.M., King, J., Mudd, P.N., Jr., et al. Selectivity and maximum response of vibegron and mirabegron for β3-adrenergic receptors. Curr. Ther. Res. Clin. Exp. 96, 100674 (2022).

    2. Togo, M., Kitta, T., Chiba, H., et al. Effects of a new selective β3-adrenoceptor agonist, vibegron, on bladder and urethral function in a rat model of Parkinson’s disease. Low. Urin. Tract Symptoms 15(6), 265-270 (2023).

    3. Shimizu, N., Gotoh, D., Nishimoto, M., et al. Efficacy of vibegron, a novel β3-adrenoreceptor agonist, for lower urinary tract dysfunction in mice with spinal cord injury. Int. J. Urol. 28(10), 1068-1072 (2021).