A prodrug form of HEX
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

POMHEX

Item No. 33390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2-dimethyl-propanoic acid, 1,1′-[[(1-hydroxy-2-oxo-3-piperidinyl)phosphinylidene]bis(oxymethylene)] ester
CAS Number
2004714-34-3
Molecular Formula
C17H30NO9P
Formula Weight
423.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C(C)(C)C)OCOP(OCOC(C(C)(C)C)=O)(C1C(N(CCC1)O)=O)=O
InChi Code
InChI=1S/C17H30NO9P/c1-16(2,3)14(20)24-10-26-28(23,12-8-7-9-18(22)13(12)19)27-11-25-15(21)17(4,5)6/h12,22H,7-11H2,1-6H3
InChi Key
TVFIFFUSHZDTKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $197

    Add

    5 mg

    $885

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    POMHEX is a prodrug form of the β-enolase, also known as enolase-3, inhibitor HEX.1 It is converted to HEX by intracellular carboxylesterases and selectively reduces the cell density of ENO1-/- D-423MG glioblastoma cells (IC50 = 38 nM) over ENO1-overexpressing D-423MG cells and LN-319 astrocytoma cells expressing wild-type ENO1 (IC50s = 604 and 2,148 nM, respectively). POMHEX decreases cell density in normoxic and hypoxic growth conditions in ENO1-/- D-423MG cells (IC50s = 79 and 201 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, V.C., Yang, K.L., Ballato, E.S., et al. Bioreducible phosphonoamidate pro-drug inhibitor of enolase: Proof of concept study. ACS Med. Chem. Lett. 11(7), 1484-1489 (2020).