A prodrug form of HEX
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POMHEX

Item No. 33390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2-dimethyl-propanoic acid, 1,1′-[[(1-hydroxy-2-oxo-3-piperidinyl)phosphinylidene]bis(oxymethylene)] ester
CAS Number
2004714-34-3
Molecular Formula
C17H30NO9P
Formula Weight
423.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C(C)(C)C)OCOP(OCOC(C(C)(C)C)=O)(C1C(N(CCC1)O)=O)=O
InChi Code
InChI=1S/C17H30NO9P/c1-16(2,3)14(20)24-10-26-28(23,12-8-7-9-18(22)13(12)19)27-11-25-15(21)17(4,5)6/h12,22H,7-11H2,1-6H3
InChi Key
TVFIFFUSHZDTKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $197

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    5 mg

    $885

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    Cayman Chemical
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    Product Description

    POMHEX is a prodrug form of the β-enolase, also known as enolase-3, inhibitor HEX.1 It is converted to HEX by intracellular carboxylesterases and selectively reduces the cell density of ENO1-/- D-423MG glioblastoma cells (IC50 = 38 nM) over ENO1-overexpressing D-423MG cells and LN-319 astrocytoma cells expressing wild-type ENO1 (IC50s = 604 and 2,148 nM, respectively). POMHEX decreases cell density in normoxic and hypoxic growth conditions in ENO1-/- D-423MG cells (IC50s = 79 and 201 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, V.C., Yang, K.L., Ballato, E.S., et al. Bioreducible phosphonoamidate pro-drug inhibitor of enolase: Proof of concept study. ACS Med. Chem. Lett. 11(7), 1484-1489 (2020).