An inhibitor of MAO-A
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Toloxatone

Item No. 33413

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone
CAS Number
29218-27-7
Synonyms
  • Humoryl
  • MD 69276
Molecular Formula
C11H13NO3
Formula Weight
207.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
239 nm
SMILES
CC1=CC(N2C(OC(CO)C2)=O)=CC=C1
InChi Code
InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
InChi Key
MXUNKHLAEDCYJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $263

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    50 mg

    $461

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    Product Description

    Toloxatone is an inhibitor of monoamine oxidase A (MAO-A; Ki = 1.8 µM).1 It is selective for MAO-A over MAO-B (Ki = 44 µM). Toloxatone (100 mg/kg) inhibits deamination of serotonin (5-HT) and norepinephrine in rat brain.2 It also decreases immobility time in the forced swim test in mice when administered at a dose of 256 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cesura, A.M., and Pletscher, A. The new generation of monoamine oxidase inhibitors. Prog. Drug Res. 38, 171-297 (1992).

    2. Keane, P.E., Kan, J.P., Sontag, N., et al. Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the rat. J. Pharm. Pharmacol. 31(11), 752-754 (1979).

    3. Van der Meersch-Mougeot, V., da Rocha, M., Jr., Monier, C., et al. Benzodiazepines reverse the anti-immobility effect of antidepressants in the forced swimming test in mice. Neuropharmacology 32(5), 439-446 (1993).