A peptide hormone
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Thymulin (acetate hydrate)

Item No. 33418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolyl-L-alanyl-L-lysyl-L-seryl-L-glutaminylglycylglycyl-L-seryl-L-asparagine, acetate, hydrate
Synonyms
  • Thymic Factor
Molecular Formula
C33H54N12O15 • XC2H4O2 [XH2O]
Formula Weight
858.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
NC(C[C@@H](C(O)=O)NC([C@H](CO)NC(CNC(CNC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O.O
InChi Code
InChI=1S/C33H54N12O15.C2H4O2.H2O/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49;1-2(3)4;/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60);1H3,(H,3,4);1H2/t15-,16-,17-,18-,19-,20-,21-;;/m0../s1
InChi Key
JQVNJWHUPXMDCN-FDZYDGOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $132

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    10 mg

    $246

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    25 mg

    $516

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    Product Description

    Thymulin is a zinc-dependent metallopeptide hormone with immunomodulatory, anti-inflammatory, and analgesic activities.1,2 It is primarily produced by thymic epithelial cells but can be produced by macrophages and fibroblasts when exposed to extracellular stressors, such as heat or oxidative stress.2 Thymulin potentiates mitogen-induced proliferation of IL-2 receptor-positive mature T cells.3 It reduces pro-inflammatory cytokine production in rodent models of LPS- or endotoxin-induced systemic inflammation, as well as prevents myocardial inflammation in a mouse model of encephalomyocarditis virus-induced myocarditis and suppresses autoantibody production in a mouse model of reovirus-induced thyroiditis.4,5 Thymulin (0.1, 0.5, and 1 µg, i.c.v.) prevents endotoxin-induced hyperalgesia in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bach, J.-F., and Dardenne, M. Thymulin, a zinc-dependent hormone. Med. Oncol. Tumor Pharmacother. 6(1), 25-29 (1989).

    2. Lunin, S.M., Khrenov, M.O., Glushkova, O.V., et al. Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosis. Int. J. Immunopathol. Pharmacol. 30(1), 58-69 (2017).

    3. Hadden, J.W. Thymic endocrinology. Ann. N. Y. Acad. Sci. 840(1), 352-358 (1998).

    4. Santos, M.A.M., Henriques-Coelho, T., and Leite-Moreira, A. Immunomodulatory role of thymulin in lung diseases. Expert Opin. Ther. Targets 14(2), 131-141 (2010).

    5. Safieh-Garabedian, B., Ochoa-Chaar, C.I., Poole, S., et al. Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection. Neuroscience 121(4), 865-873 (2003).