A positive allosteric modulator of AMPA receptors
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1-BCP

Item No. 33428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-benzodioxol-5-yl-1-piperidinyl-methanone
CAS Number
34023-62-6
Molecular Formula
C13H15NO3
Formula Weight
233.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/ml
SMILES
O=C(N1CCCCC1)C2=CC=C3OCOC3=C2
InChi Code
InChI=1S/C13H15NO3/c15-13(14-6-2-1-3-7-14)10-4-5-11-12(8-10)17-9-16-11/h4-5,8H,1-3,6-7,9H2
InChi Key
BXBNADAPIHHXJQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $80

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    10 mg

    $142

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    25 mg

    $274

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    50 mg

    $504

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    Product Description

    1-BCP is a positive allosteric modulator of AMPA receptors.1,2,3 1-BCP (1 mM) selectively increases the release of norepinephrine induced by AMPA, but not NMDA or kainic acid, in rat hippocampal slices.1 It increases the amplitude and duration of primed field excitatory postsynaptic potentials (EPSPs) in rat hippocampal slices (EC50s = 480 and 590 µM, respectively).2 1-BCP enhances memory in two-odor discrimination and radial maze tests, as well as in the Morris water maze, in rats when administered at a dose of 120 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Desai, M.A., Valli, M.J., Monn, J.A., et al. 1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices. Neuropharmacology 34(2), 141-147 (1995).

    2. Arai, A., Kessler, M.M., Xiao, P., et al. A centrally active drug that modulates AMPA receptor gated currents. Brain. Res. 638(1-2), 343-346 (1994).

    3. Staubli, U., Rogers, G., and Lynch, G. Facilitation of glutamate receptors enhances memory. Proc. Natl. Acad. Sci. USA 91(2), 777-781 (1994).