A potentiator of GABAA receptors
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Chlormethiazole (hydrochloride)

Item No. 33437

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-chloroethyl)-4-methyl-thiazole, monohydrochloride
CAS Number
6001-74-7
Synonyms
  • Clomethiazole
Molecular Formula
C6H8ClNS • HCl
Formula Weight
198.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
213, 250 nm
SMILES
CC1=C(CCCl)SC=N1.Cl
InChi Code
InChI=1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
InChi Key
OFXYKSLKNMTBHK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    50 mg

    $255

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    100 mg

    $351

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    Product Description

    Chlormethiazole is a potentiator of GABAA receptors.1 It potentiates GABA-induced currents in L-M(TK-) cells expressing α1β1γ2 or α1β2γ2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 130.8 mg/kg).2 It reduces infarct volume in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).3 Formulations containing chlormethiazole have been used in the treatment of acute alcohol withdrawal.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nelson, R.M., Green, A.R., and Hainsworth, A.H. Electrophysiological actions of γ-aminobutyric acid and clomethiazole on recombinant GABAA receptors. Eur. J. Pharmacol. 452(3), 255-262 (2002).

    2. Pilip, S., Urbańska, E.M., Swiader, M., et al. Anticonvulsant action of chlormethiazole is prevented by subconvulsive amounts of strychnine and aminophylline but not by bicuculline and picrotoxin. Pol. J. Pharmacol. 52(4), 267-273 (2000).

    3. Sydserff, S.G., Cross, A.J., and Green, A.R. The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat. Neurodegeneration 4(3), 323-328 (1995).