An internal standard for the quantification of methocarbamol
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Unlabeled Version(s)
23870Methocarbamol
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Methocarbamol-d5

Item No. 33464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-methoxyphenoxy)-1,2-propane-1,1,2,3,3-d5-diol, 1-carbamate
CAS Number
1189699-70-4
Synonyms
  • AHR 85-d5
  • Guaiacol Glyceryl Ether Carbamate-d5
  • Guaiphenesin Carbamate-d5
Molecular Formula
C11H10D5NO5
Formula Weight
246.3
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleMethanol: soluble
SMILES
NC(OC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=C(C=CC=C1)OC)=O
InChi Code
InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)/i6D2,7D2,8D
InChi Key
GNXFOGHNGIVQEH-RORPNYJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $98

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    1 mg

    $167

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    Product Description

    Methocarbamol-d5 is intended for use as an internal standard for the quantification of methocarbamol (Item No. 23870) by GC- or LC-MS. Methocarbamol is an orally bioavailable skeletal muscle relaxant.1 In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg.1,2 It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg.3 Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 μM, respectively).4 Formulations containing methocarbamol have been used to treat skeletal muscle spasms.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cymbalist, M.A., and Shapero, M. A comparative study of the effect of some centrally acting skeletal muscle relaxants in mice. J. Pharm. Pharmacol. 26(2), 109-112 (1974).

    2. Nevins, M.E., Nash, S.A., and Beardsley, P.M. Quantitative grip strength assessment as a means of evaluating muscle relaxation in mice. Psychopharmacology (Berl) 110(1-2), 92-86 (1993).

    3. Crankshaw, D.P., and Raper, C. Some studies on peripheral actions of mephenesin, methocarbamol and diazepam. Br. J. Pharmacol. 34(3), 579-590 (1968).

    4. Parr, J.S., and Khalifah, R.G. Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. The Journal of Biological Chemisty 267(35), 25044-25050 (1992).