A covalent inhibitor of c-Myc
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EN4

Item No. 33473

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-benzamide
CAS Number
1197824-15-9
Molecular Formula
C25H24N2O4
Formula Weight
416.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NCC1=CC=C(C(NC2=C(OC3=CC=C(C=C3)OCC)C=CC=C2)=O)C=C1)C=C
InChi Code
InChI=1S/C25H24N2O4/c1-3-24(28)26-17-18-9-11-19(12-10-18)25(29)27-22-7-5-6-8-23(22)31-21-15-13-20(14-16-21)30-4-2/h3,5-16H,1,4,17H2,2H3,(H,26,28)(H,27,29)
InChi Key
DKOWGKKELPCHEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $72

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    10 mg

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    25 mg

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    50 mg

    $394

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    Cayman Chemical
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    Product Description

    EN4 is a covalent inhibitor of c-Myc.1 It inhibits c-Myc-induced increases in transcriptional activity in a reporter assay using HEK293T cells (EC50 = 12.5 µM). EN4 (1, 10, or 50 µM) reduces the proliferation of 231MFP breast cancer cells. In vivo, EN4 (50 mg/kg per day) decreases tumor volume in a 231MFP mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boike, L., Cioffi, A.G., Majewski, F.C., et al. Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC. Cell Chem. Biol. 28(1), 4-13 (2021).