An internal standard for the quantification of carbamazepine
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Carbamazepine-d10

Item No. 33486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5H-dibenz[b,f]azepine-1,2,3,4,6,7,8,9,10,11-d10-5-carboxamide
CAS Number
132183-78-9
Synonyms
  • Carbazepine-d10
  • CBZ-d10
Molecular Formula
C15H2D10N2O
Formula Weight
246.3
Purity
≥99% deuterated forms (d1-d10)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 3 mg/ml
SMILES
O=C(N1C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C31)N
InChi Code
InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)/i1D,2D,3D,4D,5D,6D,7D,8D,9D,10D
InChi Key
FFGPTBGBLSHEPO-LHNTUAQVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $121

    Add

    5 mg

    $388

    Add
    Product Description

    Carbamazepine-d10 is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant.1,2 It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED50s = 15.46 and ~13 mg/kg, respectively). Dietary administration of carbamazepine (0.75% w/w) reduces immobility time in the tail suspension test.3 It also attenuates clonidine-induced aggressive behavior in mice.4 Formulations containing carbamazepine have been used in the treatment of epilepsy and bipolar disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Łuszczki, J.J., Marzeda, P., Gut-Lepiech, A., et al. New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model. Pharmacol. Rep. 71(2), 299-305 (2019).

    2. Borowicz-Reutt, K.K., Banach, M., and Rudkowska, M. Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice. Pharmacol. Rep. 72(1), 80-86 (2020).

    3. Kara, N.Z., Karpel, O., Toker, L., et al. Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice. Acta Neuropsychiatr. 26(1), 29-34 (2014).

    4. Fujiwara, Y., Takeda, T., Kazahaya, Y., et al. Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice. Int. J. Neurosci. 42(1-2), 77-84 (1988).