An inhibitor of tubulin polymerization
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Microtubule Dynamics

Research Area

Cancer
Cell Cycle
G2/M
Cell Death

Batabulin (sodium salt)

Item No. 33487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-benzenesulfonamide, monosodium salt
CAS Number
195533-98-3
Synonyms
  • T138067
Molecular Formula
C13H6F6NO3S • Na
Formula Weight
393.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
235 nm
SMILES
O=S([N-]C1=CC=C(C(F)=C1)OC)(C2=C(F)C(F)=C(F)C(F)=C2F)=O.[Na+]
InChi Code
InChI=1S/C13H6F6NO3S.Na/c1-23-7-3-2-5(4-6(7)14)20-24(21,22)13-11(18)9(16)8(15)10(17)12(13)19;/h2-4H,1H3;/q-1;+1
InChi Key
UWPXRVDIKGZQQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $95

    Add

    10 mg

    $168

    Add

    25 mg

    $370

    Add

    50 mg

    $554

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Batabulin is an inhibitor of tubulin polymerization.1 It covalently binds to cysteine 239 (Cys239) of the β1, β2, and β4 tubulin isotypes and inhibits polymerization of bovine brain tubulin (IC50 = 2 µM) in cell-free assays. Batabulin (30, 100, and 300 nM) induces cytoskeletal collapse and cell cycle arrest at the G2/M phase in MCF-7 breast cancer cells. It is cytotoxic against a panel of drug-sensitive and -resistant cancer cell lines (IC50s = 11-165 nM). Batabulin (40 mg/kg) reduces tumor volume in CCRF CEM lymphoblastic leukemia and CEM/VBL100 multidrug-resistant lymphoblastic leukemia mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shan, B., Medina, J.C., Santha, E., et al. Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors. Proc. Natl. Acad. Sci. USA 96(10), 5686-5691 (1999).