A growth hormone secretagogue and GHS-R1a agonist
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Capromorelin (tartrate)

Item No. 33488

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-propanamide, (2R,3R)-2,3-dihydroxybutanedioate
CAS Number
193273-69-7
Synonyms
  • CP 424,391-18
  • RQ-00000005
Molecular Formula
C28H35N5O4 • C4H6O6
Formula Weight
655.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
SMILES
OC([C@H](O)[C@@H](O)C(O)=O)=O.CN(C1=O)N=C(CCN(C2)C([C@H](NC(C(C)(N)C)=O)COCC3=CC=CC=C3)=O)[C@]12CC4=CC=CC=C4
InChi Code
InChI=1S/C28H35N5O4.C4H6O6/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20;5-1(3(7)8)2(6)4(9)10/h4-13,22H,14-19,29H2,1-3H3,(H,30,35);1-2,5-6H,(H,7,8)(H,9,10)/t22-,28-;1-,2-/m11/s1
InChi Key
MJGRJCMGMFLOET-MYPSAZMDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $107

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    10 mg

    $183

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    25 mg

    $378

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    Product Description

    Capromorelin is a growth hormone (GH) secretagogue and an agonist of GH secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1,2 It stimulates GH release from primary rat pituitary cells with an EC50 value of 3 nM.1 Capromorelin (0.3, 3, and 30 nM) stimulates intracellular calcium mobilization in primary rat pituitary cells. It increases rat serum GH levels (ED50 = 0.04 mg/kg, i.v.) and decreases dog serum insulin-like growth factor 1 (IGF-1) levels when administered orally at a dose of 1 mg/kg. Capromorelin (3.9 mg/kg, once per day for 28 days) increases rat body weight by 43.6% without affecting whole-body percentages of fat, lean mass, or bone content. It decreases infarct size in a rabbit model of ischemia-reperfusion injury induced by left coronary artery occlusion when administered at a dose of 25 mg/kg.3 Formulations containing capromorelin have been used in the treatment of weight loss in cats with chronic kidney disease and as an appetite stimulant in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pan, L.C., Carpino, P.A., Lefker, B.A., et al. Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine growth hormone secretagogue. Endocrine 14(1), 121-132 (2001).

    2. Rhodes, L., Zollers, B., Wofford, J.A., et al. Capromorelin: A ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs. Vet. Med. Sci. 4(1), 3-16 (2017).

    3. MacAndrew, J.T., Ellery, S.S., Parry, M.A., et al. Efficacy of a growth hormone-releasing peptide mimetic in cardiac ischemia/reperfusion injury. Eur. J. Pharmacol. 423(2-3), 195-202 (2001).