A vasoprotective agent
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Tribenoside

Item No. 33498

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
ethyl 3,5,6-tris-O-(phenylmethyl)-D-glucofuranoside
CAS Number
10310-32-4
Molecular Formula
C29H34O6
Formula Weight
478.6
Purity
≥95% (mixture of anomers)
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O[C@H]([C@H]1OCC2=CC=CC=C2)C(OCC)O[C@]1([H])[C@@H](COCC3=CC=CC=C3)OCC4=CC=CC=C4
InChi Code
InChI=1S/C29H34O6/c1-2-32-29-26(30)28(34-20-24-16-10-5-11-17-24)27(35-29)25(33-19-23-14-8-4-9-15-23)21-31-18-22-12-6-3-7-13-22/h3-17,25-30H,2,18-21H2,1H3/t25-,26-,27-,28-,29?/m1/s1
InChi Key
ULLNJSBQMBKOJH-VIVFLBMVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $41

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    100 mg

    $72

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    250 mg

    $157

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    500 mg

    $293

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    Product Description

    Tribenoside is a vasoprotective agent with anti-allergic and anti-inflammatory activities.1,2 It inhibits agonist-induced contractions in various isolated porcine venous preparations when used at concentrations ranging from 10 to 30 µg/ml.1 Tribenoside inhibits compound 48/80-induced histamine release in isolated rat peritoneal cells (EC50 = 10 µg/ml).3 It reduces decreases in proteoglycan levels and the severity of cartilage destruction in the inflamed joints in a rabbit model of surgically induced osteoarthritis when administered at doses of 100 and 200 mg/kg per day.4 Formulations containing tribenoside have been used in the treatment of hemorrhoids and varicose veins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jaques, R. The activity pattern, in isolated veins, of a benzyl glucofuranoside derivative possessing combined anti-inflammatory and venotropic effects. Pharmacology 4(4), 193-202 (1970).

    2. Jaques, R. The pharmacological activity of tribenoside. Pharmacology 15(5), 445-460 (1977).

    3. Rüegg, M., and Jaques, R. Tribenoside as an inhibitor of chemically induced histamine release. Experientia 30(4), 399-401 (1974).

    4. Colombo, C., Butler, M., Hickman, L., et al. A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum. 26(9), 1132-1139 (1983).