A COX inhibitor and an antiplatelet agent
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Pamicogrel

Item No. 33514

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-1H-pyrrole-1-acetic acid, ethyl ester
CAS Number
101001-34-7
Synonyms
  • KBT-3022
Molecular Formula
C25H24N2O4S
Formula Weight
448.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
289, 347 nm
SMILES
COC(C=C1)=CC=C1C(S2)=C(C3=CC=C(OC)C=C3)N=C2C4=CC=CN4CC(OCC)=O
InChi Code
InChI=1S/C25H24N2O4S/c1-4-31-22(28)16-27-15-5-6-21(27)25-26-23(17-7-11-19(29-2)12-8-17)24(32-25)18-9-13-20(30-3)14-10-18/h5-15H,4,16H2,1-3H3
InChi Key
ISCHOARKJADAKJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    100 mg

    $504

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    250 mg

    $1,065

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    Product Description

    Pamicogrel is a COX inhibitor and an antiplatelet agent.1,2,3 It inhibits platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or collagen in washed isolated rabbit platelets (IC50s = 1.5 and 0.43 µM, respectively).2 Pamicogrel (1 mg/kg) reduces thrombus weight in a guinea pig model of arteriovenous shunt thrombosis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Light, P. Pamicogrel (Kanebo). IDrugs 2(9), 938-942 (1999).

    2. Yokota, K., Yamamoto, N., Morimoto, Y., et al. Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions. J. Pharm. Pharmacol. 47(9), 768-774 (1995).

    3. Yokota, K., Yamashita, A., and Oda, M. Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis. Jpn. J. Pharmacol. 68(2), 201-206 (1995).