An internal standard for the quantification of enoxacin
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Unlabeled Version(s)
16956Enoxacin
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Enoxacin-d8 (hydrochloride)

Item No. 33544

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl-2,2,3,3,5,5,6,6-d8)-1,8-naphthyridine-3-carboxylic acid, monohydrochloride
CAS Number
2930288-95-0
Molecular Formula
C15H9D8FN4O3 • HCl
Formula Weight
364.8
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: warmedWater: soluble
SMILES
CCN1C2=NC(N3C([2H])([2H])C([2H])([2H])NC([2H])([2H])C3([2H])[2H])=C(F)C=C2C(C(C(O)=O)=C1)=O.Cl
InChi Code
InChI=1S/C15H17FN4O3.ClH/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20;/h7-8,17H,2-6H2,1H3,(H,22,23);1H/i3D2,4D2,5D2,6D2;
InChi Key
ODOAWCIYUUFLHN-JCYLEXHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Enoxacin-d8 is intended for use as an internal standard for the quantification of enoxacin (Item No. 16956) by GC- or LC-MS. Enoxacin is a fluoroquinolone antibiotic.1,2,3,4 It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria, including S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens (MIC50s = 1, 0.12, 0.25, 0.5, and 1 mg/L, respectively).1 Enoxacin inhibits S. aureus DNA gyrase supercoiling activity and topoisomerase IV DNA decatenation (IC50s = 126 and 26.5 µg/ml, respectively).2 It increases survival in mouse models of systemic S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens infection with ED50 values of 15.1, 2.2, 4.1, 120.3, and 7.6 mg/kg, respectively.3 Enoxacin (4 and 8 mg/kg per day) also reduces tumor growth in a 143B human osteosarcoma mouse xenograft model.4 Formulations containing enoxacin have previously been used in the treatment of urinary tract infections and gonorrhea.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clarke, A.M., Zemcov, S.J., and Campbell, M.E. In-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new β-lactams. J. Antimicrob. Chemother. 15(1), 39-44 (1985).

    2. Takei, M., Fukuda, H., Kishii, R., et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob. Agents Chemother. 45(12), 3544-3547 (2001).

    3. Ozaki, M., Matsuda, M., Tomii, Y., et al. In vivo evaluation of NM441, a new thiazeto-quinoline derivative. Antimicrob. Agents Chemother. 35(12), 2496-2499 (1991).

    4. Luo, X., Liu, X., Tao, Q., et al. Enoxacin inhibits proliferation and invasion of human osteosarcoma cells and reduces bone tumour volume in a murine xenograft model. Oncol. Lett. 20(2), 1400-1408 (2020).