A deoxyribonucleotide
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5'-Thymidylic Acid (sodium salt)

Item No. 33549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
33430-62-5
Synonyms
  • Deoxythymidine-5’-monophosphate
  • Thymidine monophosphate
  • Thymidine-5’-monophosphate
  • dTMP
Molecular Formula
C10H13N2O8P • 2Na
Formula Weight
366.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): slightly soluble
λmax
268 nm
SMILES
O=C(N1)C(C)=CN([C@@]2([H])C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C1=O.[Na+].[Na+]
InChi Code
InChI=1S/C10H15N2O8P.2Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18);;/q;2*+1/p-2/t6-,7+,8+;;/m0../s1
InChi Key
AGSQMPPRYZYDFV-ZJWYQBPBSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $38

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    250 mg

    $71

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    1 g

    $238

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    Product Description

    5'-Thymidylic acid (dTMP) is a deoxyribonucleotide.1 It is formed via methylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis.2 Oral administration of dTMP in combination with dCMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Nucleotide biosynthesis. Biochemistry (2002).

    2. Lee, L.S., and Cheng, Y. Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia. The Journal of Biological Chemisty 252(16), 5686-5691 (1977).

    3. Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al. Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency. Ann. Neurol. 81(5), 641-652 (2017).