A dopamine D1 and D5 receptor partial agonist
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PF-06649751

Item No. 33556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,5-dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione
CAS Number
1643489-24-0
Synonyms
  • CVL-751
Molecular Formula
C19H16F3N3O3
Formula Weight
391.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.05 mg/mlEthanol: 2 mg/ml
λmax
273 nm
SMILES
O=C1NC(N(C)C(C2=C(C)C=C(OC3=NC=CC=C3C(F)(F)F)C=C2)=C1C)=O
InChi Code
InChI=1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)
InChi Key
AKQXQLUNFKDZBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $84

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    25 mg

    $185

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    50 mg

    $304

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    Product Description

    PF-06649751 is a dopamine D1 and D5 receptor partial agonist.1 It increases locomotor activity and reduces a global parkinsonian disability score in a macaque model of Parkinson’s disease induced by MPTP when administered at a dose of 0.04 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Young, D., Popiolek, M., Trapa, P., et al. D1 agonist improved movement of parkinsonian nonhuman primates with limited dyskinesia side effects. ACS Chem. Neurosci. 11(4), 560-566 (2020).