A PARP7 inhibitor
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RBN-2397

Item No. 33558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[(1S)-1-methyl-2-[3-oxo-3-[4-[5-(trifluoromethyl)-2-pyrimidinyl]-1-piperazinyl]propoxy]ethyl]amino]-4-(trifluoromethyl)-3(2H)-pyridazinone
CAS Number
2381037-82-5
Molecular Formula
C20H23F6N7O3
Formula Weight
523.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
221, 254 nm
SMILES
FC(F)(C1=C(C=NNC1=O)N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)F
InChi Code
InChI=1S/C20H23F6N7O3/c1-12(30-14-10-29-31-17(35)16(14)20(24,25)26)11-36-7-2-15(34)32-3-5-33(6-4-32)18-27-8-13(9-28-18)19(21,22)23/h8-10,12H,2-7,11H2,1H3,(H2,30,31,35)/t12-/m0/s1
InChi Key
UQZCQKXJAXKZQH-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $269

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    10 mg

    $455

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    Product Description

    RBN-2397 is an inhibitor of poly(ADP-ribose) polymerase 7 (PARP7).1 It stabilizes wild-type PARP7 levels, but not levels of the catalytically inactive mutant PARP7H532A, in COS-1 cells expressing wild-type or mutant PARP7, respectively, when used at a concentration of 100 nM. RBN-2397 (100 nM) also decreases wild-type PARP7 catalytic activity in the same cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rasmussen, M., Tan, S., Somisetty, V.S., et al. PARP7 and Mono-ADP-Ribosylation negatively regulate estrogen receptor α signaling in human breast cancer cells. Cells 10, 623 (2021).