An Mtb CdnP inhibitor
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C82

Item No. 33563

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-ethyl-N-(2-methoxyphenyl)-4-oxo-thieno[2,3-d]pyrimidine-3(4H)-acetamide
CAS Number
691862-35-8
Molecular Formula
C17H17N3O3S
Formula Weight
343.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
λmax
238, 290 nm
SMILES
O=C1C2=C(N=CN1CC(NC3=C(OC)C=CC=C3)=O)SC(CC)=C2
InChi Code
InChI=1S/C17H17N3O3S/c1-3-11-8-12-16(24-11)18-10-20(17(12)22)9-15(21)19-13-6-4-5-7-14(13)23-2/h4-8,10H,3,9H2,1-2H3,(H,19,21)
InChi Key
JHEASKMQXRYFDN-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    10 mg

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    Cayman Chemical
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    Product Description

    C82 is an inhibitor of M. tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP; IC50 = 17.5 µM), the enzyme that catalyzes the hydrolysis of cyclic di-AMP (c-di-AMP; Item No. 17753) to adenosine 5'-monophosphate (AMP; Item No. 21094).1 It is selective for Mtb CdnP over the additional bacterial CDN phosphodiesterases (PDEs) Yybt, RocR, and group B streptococcus (GBS) CdnP, the mammalian CDN PDE ENPP1, and the viral CDN PDE poxin at 200 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karanja, C.W., Yeboah, K.S., and Sintim, H.O. Identification of a Mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase inhibitor. ACS Infect. Dis. 7(2), 309-317 (2021).