An inhibitor of late-stage autophagy
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Autophagy
Cell Death
Apoptosis

PHY34

Item No. 33584

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-[[3,4-O-(1-methylethylidene)-β-D-galactopyranosyl]oxy]-naphtho[2,3-c]furan-1(3H)-one
CAS Number
2130033-55-3
Molecular Formula
C30H30O12
Formula Weight
582.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
263 nm
SMILES
O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@H]6[C@@H]([C@]7([H])[C@](OC(C)(O7)C)([H])[C@H](O6)CO)O)=C2CO1
InChi Code
InChI=1S/C30H30O12/c1-30(2)41-26-21(10-31)39-29(24(32)27(26)42-30)40-25-15-9-19(35-4)18(34-3)8-14(15)22(23-16(25)11-36-28(23)33)13-5-6-17-20(7-13)38-12-37-17/h5-9,21,24,26-27,29,31-32H,10-12H2,1-4H3/t21-,24-,26+,27-,29+/m1/s1
InChi Key
PMJUVXNBXQVOOP-NXMNBGQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $794

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    Product Description

    PHY34 is an inhibitor of late-stage autophagy.1 It is cytotoxic to OVCAR-3 and OVCAR-8 ovarian cancer cells (IC50 = 4 nM for both) and induces apoptosis in the same cells when used at a concentration of 100 nM. PHY34 increases the number of LC3B puncta and induces autophagosome accumulation in HeLa cells (EC50s = 1.99 and 3.86 nM, respectively). It reduces tumor growth in an OVCAR-8 mouse xenograft model when administered at a dose of 0.75 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Young, A.N., Herrera, D., Huntsman, A.C., et al. Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high-grade serous ovarian cancer by late-stage autophagy inhibition. Mol. Cancer Ther. 17(10), 2123-2135 (2018).