A quinolone antibiotic
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Garenoxacin

Item No. 33599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS Number
194804-75-6
Synonyms
  • BMS-284756
  • T-3811ME
Molecular Formula
C23H20F2N2O4
Formula Weight
426.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
λmax
221, 286 nm
SMILES
C[C@@H]1NCC2=CC(C3=CC=C(C(C(C(O)=O)=CN4C5CC5)=O)C4=C3OC(F)F)=CC=C12
InChi Code
InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m0/s1
InChi Key
NJDRXTDGYFKORP-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Garenoxacin is a quinolone antibiotic.1 It is active against a variety of Gram-positive and Gram-negative bacteria (MIC90s = 0.025-6.25 and 0.0125-100 µg/ml, respectively). Garenoxacin inhibits E. coli DNA gyrase supercoiling and S. aureus topoisomerase IV decatenation activities (IC50s = 0.17 and 2.19 mg/L, respectively).2 It is selective for S. aureus topoisomerase IV over human topoisomerase II (IC50 = 509.7 µg/L). Garenoxacin is efficacious against systemic quinolone-resistant S. aureus infection and pneumonia induced by the penicillin-resistant S. pneumoniae clinical isolate D-979 in mice (ED50s = 0.0189 and 0.0278 mg/animal, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takahata, M., Mitsuyama, J., Yamashiro, Y., et al. In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone. Antimicrob. Agents Chemother. 43(5), 1077-1084 (1999).

    2. Lawrence, L.E., Wu, P., Fan, L., et al. The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues. J. Antimicrob. Chemother. 48(2), 195-201 (2001).