An internal standard for the quantification of barnidipine
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Unlabeled Version(s)
20448Barnidipine (hydrochloride)
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Barnidipine-d5 (hydrochloride)

Item No. 33609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-((phenyl-d5)methyl)-3-pyrrolidinyl] ester, monohydrochloride
Synonyms
  • YM-09730-5-d5
Molecular Formula
C27H24D5N3O6 • HCl
Formula Weight
533.0
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
CC1=C(C(O[C@@H]2CN(CC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])CC2)=O)[C@H](C(C(OC)=O)=C(C)N1)C4=CC([N+]([O-])=O)=CC=C4.Cl
InChi Code
InChI=1S/C27H29N3O6.ClH/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19;/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3;1H/t22-,25-;/m0./s1/i4D,5D,6D,8D,9D;
InChi Key
XEMPUKIZUCIZEY-MWQBNHTBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $248

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    5 mg

    $1,052

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    Product Description

    Barnidipine-d5 (hydrochloride) is intended for use as an internal standard for the quantification of barnidipine (Item No. 20448) by GC- or LC-MS. Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.1 It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.2 Formulations containing barnidipine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakayama, K., Kashiwabara, T., Yamada, S., et al. Assessment in pig coronary artery of long-lasting and potent calcium antagonistic actions of the novel dihydropyridine derivative mepirodipine hydrochloride. Arzneimittelforschung 39(1), 50-55 (1989).

    2. Kawashima, K., Toda, H., Oohata, H., et al. Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats. Gen. Pharmacol. 22(2), 263-266 (1991).