A P2X7 receptor antagonist
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ITH15004

Item No. 33667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(6-chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)-ethanone
CAS Number
2600675-12-3
Molecular Formula
C13H7Cl3N4O
Formula Weight
341.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 10 mg/ml
λmax
260 nm
SMILES
O=C(C1=CC=C(Cl)C=C1Cl)CN2C=NC3=C(Cl)N=CN=C23
InChi Code
InChI=1S/C13H7Cl3N4O/c14-7-1-2-8(9(15)3-7)10(21)4-20-6-19-11-12(16)17-5-18-13(11)20/h1-3,5-6H,4H2
InChi Key
NLRGSGVPLHCTPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $160

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    10 mg

    $303

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    25 mg

    $629

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    Cayman Chemical
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    Product Description

    ITH15004 is a non-nucleotide antagonist of the purinergic P2X7 receptor (IC50 = 9 µM in HEK293 cells expressing the human receptor).1 It inhibits ATP-induced currents in X. laevis oocytes expressing the human P2X7 receptor when used at a concentration of 100 µM. ITH15004 (1 µM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Calzaferri, F., Narros-Fernández, P., de Pascual, R., et al. Synthesis and pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation. J. Med. Chem. 64(4), 2272-2290 (2021).