A dipeptide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Homocarnosine

Item No. 33695

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-amino-1-oxobutyl)-L-histidine
CAS Number
3650-73-5
Synonyms
  • γ-Aminobutyrylhistidine
  • γ-Aminobutyryl-L-histidine
  • NSC 92522
Molecular Formula
C10H16N4O3
Formula Weight
240.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC([C@H](CC1=CN=CN1)NC(CCCN)=O)=O
InChi Code
InChI=1S/C10H16N4O3/c11-3-1-2-9(15)14-8(10(16)17)4-7-5-12-6-13-7/h5-6,8H,1-4,11H2,(H,12,13)(H,14,15)(H,16,17)/t8-/m0/s1
InChi Key
CCLQKVKJOGVQLU-QMMMGPOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

    Add

    5 mg

    $213

    Add

    10 mg

    $376

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Homocarnosine is a dipeptide composed of GABA and L-histidine that has been found in cerebrospinal fluid and the brain.1 It inhibits lipid peroxidation induced by AAPH (Item No. 82235) when used at a concentration of 10 mM.2 Homocarnosine (1 mM) decreases lactate dehydrogenase (LDH) and prostaglandin E2 (PGE2; Item No. 14010) release from PC12 cells in an in vitro model of ischemia induced by oxygen-glucose deprivation.3 It reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).4 Homocarnosine (5 mg/animal) reduces mortality in a mouse model of subcutaneous S. aureus infection.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crush, K.G. Carnosine and related substances in animal tissues. Comp. Biochem. Physiol. 34(1), 3-30 (1970).

    2. Kohen, R., Yamamoto, Y., Cundy, K.C., et al. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc. Natl. Acad. Sci. USA 85(9), 3175-3179 (1988).

    3. Tabakman, R., Lazarovici, P., and Kohen, R. Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J. Neurosci. Res. 68(4), 463-469 (2002).

    4. Huang, J., Wang, T., Yu, D., et al. L-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasome. Int. J. Biol. Macromol. 118(Pt A), 357-364 (2018).

    5. Mukkada, A.J., Nutini, L.G., and Cook, E.S. Prophylactic effects of γ-aminobutyrylhistidine (homocarnosine) on experimental staphylococcal infections in mice. Appl. Microbiol. 18(4), 641-645 (1969).