A positive allosteric modulator of muscarinic M5 receptors
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VU0365114

Item No. 33709

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-([1,1′-biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)-1H-indole-2,3-dione
CAS Number
1208222-39-2
Molecular Formula
C22H14F3NO3
Formula Weight
397.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
λmax
248 nm
SMILES
O=C1C(N(CC2=CC=C(C3=CC=CC=C3)C=C2)C4=CC=C(C=C14)OC(F)(F)F)=O
InChi Code
InChI=1S/C22H14F3NO3/c23-22(24,25)29-17-10-11-19-18(12-17)20(27)21(28)26(19)13-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-12H,13H2
InChi Key
SPBGRXOPAXZSER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $157

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    50 mg

    $522

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    100 mg

    $783

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    Product Description

    VU0365114 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs).1 It increases ACh-induced calcium mobilization in CHO cells expressing human M5 mAChRs (EC50 = 2.7 µM) selectively over CHO cells expressing human M1-4 mAChRs (EC50s = >30 µM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bridges, T.M., Kennedy, J.P., Hopkins, C.R., et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg. Med. Chem. Lett. 20(19), 5617-5622 (2010).