An internal standard for the quantification of nepafenac
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Unlabeled Version(s)
23700Nepafenac
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Nepafenac-d5

Item No. 33717

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-3-(benzoyl-d5)-benzeneacetamide
CAS Number
1246814-53-8
Synonyms
  • AHR 9434-d5
  • AL 6515-d5
Molecular Formula
C15H9D5N2O2
Formula Weight
259.3
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: soluble
SMILES
O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C2=C(C(CC(N)=O)=CC=C2)N
InChi Code
InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)/i1D,2D,3D,5D,6D
InChi Key
QEFAQIPZVLVERP-XFEWCBMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Product Description

    Nepafenac-d5 is intended for use as an internal standard for the quantification of nepafenac (Item No. 23700) by GC- or LC-MS. Nepafenac is a prodrug form of amfenac, a non-steroidal anti-inflammatory drug (NSAID) and an inhibitor of COX-1 and COX-2.1 Nepafenac is an inhibitor of prostaglandin (PG) synthase 1 (IC50 = 64.3 µM) that inhibits the production of PGs in isolated rabbit iris/ciliary body.2 It also reduces protein and PGE2 (Item No. 14010) accumulation in a rabbit model of acute ocular inflammation when applied topically at a concentration of 0.1% prior to paracentesis. Formulations containing nepafenac have been used in the treatment of pain and inflammation associated with cataract surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gamache, D.A., Graff, G., Brady, M.T., et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation 24(4), 357-370 (2000).

    2. Ke, T.L., Graff, G., Spellman, J.M., et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation 24(4), 371-384 (2000).