An antibiotic
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Pipemidic Acid (hydrate)

Item No. 33719

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido[2,3-d]pyrimidine-6-carboxylic acid, trihydrate
CAS Number
72571-82-5
Molecular Formula
C14H17N5O3 • 3H2O
Formula Weight
357.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.50 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
280 nm
SMILES
O=C(C1=CN(CC)C2=NC(N3CCNCC3)=NC=C2C1=O)O.O.O.O
InChi Code
InChI=1S/C14H17N5O3.3H2O/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19;;;/h7-8,15H,2-6H2,1H3,(H,21,22);3*1H2
InChi Key
URMXYPLWYMOYPG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Pipemidic acid is an antibiotic and derivative of piromidic acid (Item No. 19255).1 It is active against clinical isolates of E. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, and V. parahaemolyticus (MICs = 0.78-100 µg/ml), as well as drug-resistant clinical isolates of E. coli, P. mirabilis, Klebsiella, and Shigella (MICs = 1.56-6.25 µg/ml). Pipemidic acid is protective against systemic S. aureus, E. coli, K. pneumoniae, and P. aeruginosa infections in mice (ED50s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively).2 It is also protective against P. aeruginosa-induced pulmonary and dermal infections (ED50s = 81.7 and 173.2 mg/kg, respectively), as well as E. coli, K. pneumoniae, and P. aeruginosa urinary bladder infections (ED50s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimizu, Y., Takase, Y., Nakamura, S., et al. Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: In vitro properties. Antimicrob. Agents Chemother. 8(2), 132-138 (1975).

    2. Shimizu, M., Takdase, Y., Nakamura, S., et al. Pipemidic acid: Its activities against various experimental infections. Antimicrob. Agents Chemother. 9(4), 569-574 (1976).