A diterpene acid with diverse biological activities
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Dehydroabietic Acid

Item No. 33722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid
CAS Number
1740-19-8
Synonyms
  • (+)-Dehydroabietic Acid
  • NSC 2952
Molecular Formula
C20H28O2
Formula Weight
300.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
SMILES
C[C@@]12[C@](CCC3=CC(C(C)C)=CC=C32)([H])[C@@](C)(CCC1)C(O)=O
InChi Code
InChI=1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1
InChi Key
NFWKVWVWBFBAOV-MISYRCLQSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    250 mg

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    500 mg

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    Product Description

    Dehydroabietic acid is a diterpene acid that has been found in P. elliottii resin and has diverse biological activities.1,2,3 It is active against L. amazonensis promastigotes (IC50 = 40 µg/ml).1 Dehydroabietic acid (2.5, 5, and 10 µM) increases the number of mitochondrial ridges, decreases mitochondrial outer membrane rupture, and increases the expression of FSP1 and COQ10 in an HL7720 cell model of ferroptosis induced by oleic acid (Item Nos. 90260 | 24659).2 In vivo, dehydroabietic acid (10 and 20 mg/kg) reduces hepatic total cholesterol and triglyceride levels, ferroptosis, and lipid peroxidation in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). Dehydroabietic acid is also found in wood industry effluents and is considered a pollutant.3 It increases oxygen consumption and cellular heat production and reduces cellular ATP content in isolated rainbow trout (O. mykiss) hepatocytes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gonçalves, M.D., Bortoleti, B.T.S., Tomiotto-Pellissier, F., et al. Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis. Fitoterapia 128, 224-232 (2018).

    2. Gao, G., Xie, Z., Li, E.-W., et al. Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis. J. Nat. Med. (2021).

    3. Rissanen, E., Krumschnabel, G., and Nikinmaa, M. Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquat. Toxicol. 62(1), 45-53 (2003).