An inhibitor of bacterial DNA repair
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IMP-1700

Item No. 33724

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-3-quinolinecarboxylic acid
CAS Number
1458674-25-3
Molecular Formula
C25H22F4N4O3S
Formula Weight
534.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: slightly soluble
λmax
283 nm
SMILES
O=C(C1=CN(C2CC2)C3=CC(N4CCN(CC4)C(NC5=CC=C(C(F)(F)F)C=C5)=S)=C(C=C3C1=O)F)O
InChi Code
InChI=1S/C25H22F4N4O3S/c26-19-11-17-20(33(16-5-6-16)13-18(22(17)34)23(35)36)12-21(19)31-7-9-32(10-8-31)24(37)30-15-3-1-14(2-4-15)25(27,28)29/h1-4,11-13,16H,5-10H2,(H,30,37)(H,35,36)
InChi Key
DMUZWIXJZNKJPP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    IMP-1700 is an inhibitor of bacterial DNA repair.1 It potentiates the activity of the quinolone antibiotic ciprofloxacin (Item No. 14286) against methicillin-resistant S. aureus (MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active against E. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lim, C.S.Q., Ha, K.P., Clarke, R.S., et al. Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus. Bioorg. Med. Chem. 27(20), 114962 (2019).