Myrislignan

Myrislignan is a lignan that has been found in M. fragrans and has diverse biological activities.^1,2,3,4 It inhibits hypocotyl or root growth of cress (IC₅₀s = 429 and 517 µM, respectively).¹ Myrislignan (50 µg/ml) inhibits production of nitric oxide (NO), increases in inducible nitric oxide synthase (iNOS) and COX-2 levels, and release of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells.² It inhibits the proliferation of, and induces apoptosis in, A549 lung cancer cells.³ Myrislignan (3, 5, and 8 mg/kg) reduces tumor growth in an A549 lung cancer mouse xenograft model. It decreases parasite burden in the liver, brain, and spleen in a mouse model of T. gondii infection when administered at a dose of 100 mg/kg.⁴

WARNING This product is not for human or veterinary use.

1. Suwitchayanon, P., Suenaga, K., Iwasaki, A., et al. Myrislignan, a growth inhibitor from the roots of citronella grass. Nat. Prod. Commun. 12(7), 1077-1078 (2017).

2. Jin, H., Zhu, Z.-G., Yu, P.-J., et al. Myrislignan attenuates lipopolysaccharide-induced inflammation reaction in murine macrophage cells through inhibition of NF-κB signalling pathway activation. Phytother. Res. 26(9), 1320-1326 (2012).

3. Lu, X., Yang, L., Chen, J., et al. The action and mechanism of myrislignan on A549 cells in vitro and in vivo. J. Nat. Med. 71(1), 76-85 (2017).

4. Zhang, J., Si, H., Li., B., et al. Myrislignan exhibits activities against Toxoplasma gondii RH strain by triggering mitochondrial dysfunction. Front. Microbiol. 10, 2152 (2019).