A HIF-1 inhibitor
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SYP-5

Item No. 33791

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-2-propen-1-one
CAS Number
1384268-04-5
Molecular Formula
C18H16O3S
Formula Weight
312.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 1 mg/ml
λmax
233, 283, 369 nm
SMILES
OC1=C2C(OC(C)(C=C2)C)=CC=C1C(/C=C/C3=CC=CS3)=O
InChi Code
InChI=1S/C18H16O3S/c1-18(2)10-9-14-16(21-18)8-6-13(17(14)20)15(19)7-5-12-4-3-11-22-12/h3-11,20H,1-2H3/b7-5+
InChi Key
OMVURDVBYIJCOI-FNORWQNLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    SYP-5 is an inhibitor of hypoxia-inducible factor-1 (HIF-1).1 It inhibits HIF-1 activity in a reporter assay when used at concentrations ranging from 0.1 to 100 µM. SYP-5 (2, 10, and 50 µM) reduces hypoxia- or VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs). It inhibits the migration and invasion of Hep3B hepatocellular carcinoma and BCaP-37 breast cancer cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, L.-H., Jiang, X.-R., Yang, J.-Y., et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur. J. Pharmacol. 791, 560-568 (2016).