A potential impurity found in commercial preparations of olanzapine
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Olanzapine Lactam Impurity

Item No. 33792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z)-1,3-dihydro-4-(4-methyl-1-piperazinyl)-3-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one
CAS Number
1017241-34-7
Molecular Formula
C17H20N4O2
Formula Weight
312.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
CC(/C=C1C(N2CCN(CC2)C)=NC3=CC=CC=C3NC/1=O)=O
InChi Code
InChI=1S/C17H20N4O2/c1-12(22)11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)23/h3-6,11H,7-10H2,1-2H3,(H,19,23)/b13-11-
InChi Key
MJPUVQLOQVCMBU-QBFSEMIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $271

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    Product Description

    Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1 It is a degradation product formed by exposure to thermal or oxidative stress.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baertschi, S.W., Brunner, H., Bunnell, C.A., et al. Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulations. J. Pharm. Sci. 97(2), 883-892 (2008).