A phagocytosis-stimulating peptide
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Tuftsin (human) (trifluoroacetate salt)

Item No. 33804

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threonyl-L-lysyl-L-prolyl-L-arginine, trifluoroacetate salt
Synonyms
  • Thr-Lys-Pro-Arg
Molecular Formula
C21H40N8O6 • XCF3COOH
Formula Weight
500.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[C@@H](O)[C@H](N)C(N[C@@H](CCCCN)C(N1[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCC1)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C21H40N8O6.C2HF3O2/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25;3-2(4,5)1(6)7/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26);(H,6,7)/t12-,13+,14+,15+,16+;/m1./s1
InChi Key
FMTUDMCZOOBIBT-GYFKHDNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    Product Description

    Tuftsin is an endogenous peptide generated by proteolysis of leukokinin that stimulates phagocytosis.1 It binds human polymorphonuclear leukocytes (PMN), human monocytes, and mouse macrophages with Kd values of 130, 125, and 53 nM, respectively.2 Tuftsin (200 nM) increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages. It increases phagocytosis of the bacteria S. aureus and L. monocytogenes, as well as the fungus S. oviformis, by isolated human, mouse, rabbit, dog, or guinea pig phagocytes when used at concentrations ranging from 0.01 to 0.15 µg/ml.3 Tuftsin (0.1, 0.5, and 25 mg/kg) increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Najjar, V.A., and Nishioka, K. "Tuftsin": A natural phagocytosis stimulating peptide. Nature 228(5272), 672-673 (1970).

    2. Gottlieb, P., Stabinsky, Y., Hiller, T., et al. Tuftsin receptors. Ann. N. Y. Acad. Sci. 419, 93-106 (1983).

    3. Martinez, J., and Winternitz, F. Bactericidal activity of tuftsin. Mol. Cell Biochem. 41, 123-136 (1981).

    4. Catane, R., Schlanger, S., Weiss, L., et al. Toxicology and antitumor activity of tuftsin. Ann. N. Y. Acad. Sci. 419, 251-260 (1983).