An internal standard for the quantification of flavoxate
Related Products
Unlabeled Version(s)
19096Flavoxate (hydrochloride)
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Flavoxate-d5

Item No. 33816

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-4-oxo-2-phenyl-d5-4H-1-benzopyran-8-carboxylic acid, 2-(1-piperidinyl)ethyl ester
CAS Number
2748541-85-5
Molecular Formula
C24H20D5NO4
Formula Weight
396.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: soluble
SMILES
CC1=C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])OC3=C(C(OCCN4CCCCC4)=O)C=CC=C3C1=O
InChi Code
InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3/i2D,4D,5D,9D,10D
InChi Key
SPIUTQOUKAMGCX-ONXRJODMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Flavoxate-d5 is intended for use as an internal standard for the quantification of flavoxate (Item No. 19096) by GC- or LC-MS. Flavoxate is an inhibitor of L-type calcium channels and an antimuscarinic agent.1 It induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces contractions induced by the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) or calcium in isolated rat detrusor strips.1,2 Microinjection of flavoxate (0.68 µg/animal) into the oral pontine reticular nucleus inhibits reflex micturition in decerebrated cats, and intravenous or intracerebroventricular administration reduces isovolumetric rhythmic bladder contractions in rats.2 Formulations containing flavoxate have previously been used in the treatment of frequent or urgent urination, increased nocturnal urination, bladder pain, and urinary incontinence.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tomoda, T., Aishima, M., Takano, N., et al. The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder. Brit. J. Pharmacol. 146(1), 25-32 (2005).

    2. Kimura, Y., Sasaki, Y., Hamada, K., et al. Mechanisms of the suppression of the bladder activity by flavoxate. Int. J. Urol. 3(3), 218-227 (1996).