A sesquiterpene with diverse biological activities
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Aromadendrene

Item No. 33829

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1aR,4aR,7R,7aR,7bS)-decahydro-1,1,7-trimethyl-4-methylene-1H-cycloprop[e]azulene
CAS Number
489-39-4
Synonyms
  • (+)-Aromadendrene
  • 10(14)-Aromadendrene
Molecular Formula
C15H24
Formula Weight
204.4
Purity
≥80%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
CC1([C@@]2([H])[C@@]3([H])[C@](CC[C@H]3C)([H])C(CC[C@]21[H])=C)C
InChi Code
InChI=1S/C15H24/c1-9-6-8-12-14(15(12,3)4)13-10(2)5-7-11(9)13/h10-14H,1,5-8H2,2-4H3/t10-,11+,12-,13-,14-/m1/s1
InChi Key
ITYNGVSTWVVPIC-XVIXHAIJSA-N
Origin
Plant/Eucalyptus globulus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $80

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    25 mg

    $173

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    Product Description

    Aromadendrene is a sesquiterpene that has been found in E. globulus and has diverse biological activities.1,2,3 It is active against various strains of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE; MICs = 0.25-1 mg/ml).1 Aromadendrene (1 mM) inhibits tert-butyl hydroperoxide-induced formation of thiobarbituric acid reactive substances (TBARS) in isolated rat liver hepatocytes.2 It inhibits the proliferation of HepG2 liver and PC3 prostate cancer cells (IC50s = 20 and 9.3 µM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mulyaningsih, S., Sporer, F., Reichling, J., et al. Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens. Pharm. Biol. 49(9), 893-899 (2011).

    2. Vinholes, J., Rudnitskaya, A., Gonçalves, P., et al. Hepatoprotection of sesquiterpenoids: a quantitative structure-activity relationship (QSAR) approach. Food Chem. 146, 78-84 (2014).

    3. Al-Lihaibi, S.S., Alarif, W.M., Abdel-Lateff, A., et al. Three new cembranoid-type diterpenes from Red Sea soft coral Sarcophyton glaucum: isolation and antiproliferative activity against HepG2 cells. Eur. J. Med. Chem. 81, 314-322 (2014).