(+)-Oxypeucedanin hydrate

(+)-Oxypeucedanin hydrate is a furanocoumarin that has been found in A. japonica and has diverse biological activities.^1,2,3 It is active against the Gram-positive bacteria B. cereus, S. aureus, and S. faecalis (MICs = 9.76-78.12 µg/ml), the Gram-negative bacteria E. coli, S. dysenteriae, P. aeruginosa, K. pneumoniae, and S. typhi (MICs = 39.06-625 µg/ml), and the fungi C. albicans and M. audouinii (MIC = 39.06 µg/ml for both).² (+)-Oxypeucedanin hydrate inhibits proliferation of human MK-1 gastric and HeLa cervical cancer cells, as well as murine B16/F10 melanoma cells (EC₅₀s = 47.2, 80.3, and 42 µg/ml, respectively).¹ It also inhibits proliferation of sensitive and multidrug-resistant murine L5178Y lymphoma cells (IC₅₀s = 41.96 and 60.58 µM, respectively).³

WARNING This product is not for human or veterinary use.

1. Fujioka, T., Furumi, K., Fuhii, H., et al. Antiproliferative constituents from Umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica. Chem. Pharm. Bull. (Tokyo) 47(1), 96-100 (1999).

2. Dongfack, M.D.J., Lallemand, M.-C., Kuete, V., et al. A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperata. Chem. Pharm. Bull. (Tokyo) 60(8), 1072-1075 (2012).

3. Mottaghipisheh, J., Nové, M., Spengler, G., et al. Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia. Pharm. Biol. 56(1), 658-664 (2018).