A macrolide antibiotic
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Tylvalosin (tartrate)

Item No. 33849

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-acetate 4B-(3-methylbutanoate)tylosin, 2R,3R-dihydroxybutanedioate
CAS Number
63428-13-7
Synonyms
  • Acetylisovaleryltylosin tartrate
Molecular Formula
C53H87NO19 • XC4H6O6
Formula Weight
1042.3
Purity
≥80%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): slightly soluble
λmax
290 nm
SMILES
OC([C@H](O)[C@@H](O)C(O)=O)=O.CN(C)[C@H]([C@H]([C@@H](O[C@@H]1C)O[C@H]2[C@H](C[C@H](C(/C=C/C(C)=C/[C@@H]([C@H](OC(C[C@H]([C@@H]2C)OC(C)=O)=O)CC)CO[C@H]3[C@@H]([C@@H]([C@@H]([C@H](O3)C)O)OC)OC)=O)C)CC=O)O)[C@@H]1O[C@H]4C[C@@](O)([C@H]([C@@H](O4)C)OC(CC(C)C)=O)C
InChi Code
InChI=1S/C53H87NO19.C4H6O6/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3;5-1(3(7)8)2(6)4(9)10/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3;1-2,5-6H,(H,7,8)(H,9,10)/b18-17+,28-22+;/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-;1-,2-/m11/s1
InChi Key
OLLSDNUHBJHKJS-XKORHJEPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Tylvalosin is a macrolide antibiotic.1 It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 µg/ml, respectively). Tylvalosin (5 and 10 µg/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 (PGE2; Item No. 14010), and nitric oxide in RAW 264.7 cells.2 It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water.3 Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, B., Lei, Z., Zhao, Y., et al. Combination susceptibility testing of common antimicrobials in vitro and the effects of sub-MIC of antimicrobials on Staphylococcus aureus biofilm formation. Front. Microbiol. 8, 2125 (2017).

    2. Zhao, Z., Tang, X., Zhao, X., et al. Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Biochem. Pharmacol. 90(1), 73-87 (2014).

    3. Lopez Rodriguez, A., Berge, A.C., Ramage, C., et al. Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigs. Porcine Health Manag. 6(1), 39 (2020).