An inhibitor of SMYD3
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BCI-121

Item No. 33854

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide
CAS Number
432529-82-3
Molecular Formula
C14H18BrN3O2
Formula Weight
340.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: 10 mg/ml
λmax
253 nm
SMILES
O=C(C1CCN(CC1)CC(NC2=CC=C(C=C2)Br)=O)N
InChi Code
InChI=1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4,10H,5-9H2,(H2,16,20)(H,17,19)
InChi Key
KSUYPIXCRPCPGF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $171

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    25 mg

    $318

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    50 mg

    $528

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    Cayman Chemical
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    Product Description

    BCI-121 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3).1 It inhibits histone H3 lysine 4 (H3K4) di- and trimethylation in HT-29 cell lysates when used at a concentration of 100 µM. BCI-121 (100 µM) inhibits proliferation in a panel of colorectal, lung, pancreatic, prostate, and ovarian cancer cell lines in an SMYD3 expression-dependent manner. It induces cell cycle arrest at the S phase and decreases global H5K4 methylation and H3K4 dimethylation in HT-29 cells in a concentration-dependent manner. Intratumoral injection of BCI-121 (20 µM) reduces tumor volume in an MHCC97H hepatocellular carcinoma (HCC) mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peserico, A., Germani, A., Sanese, P., et al. A SMYD3 small-molecule inhibitor impairing cancer cell growth. J. Cell. Physiol. 230(10), 2447-2460 (2015).

    2. Wang, Y., Xie, B.-H., Lin, W.-H., et al. Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2. Oncogene 38(25), 4948-4961 (2019).