A prodrug form of AT-9010
Related Products
Alternative(s)
33870AT-511 (hemisulfate)
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AT-511

Item No. 33869

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[P(S),2′R]-2-amino-2′-deoxy-2′-fluoro-N,2′-dimethyl-P-phenyl-5′-adenylyl]-L-alanine, 1-methylethyl ester
CAS Number
1998705-64-8
Synonyms
  • AT-527
Molecular Formula
C24H33FN7O7P
Formula Weight
581.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
221, 283 nm
SMILES
CC(C)OC([C@H](C)N[P@](OC[C@@H]1[C@@H](O)[C@](F)(C)[C@]([H])(N2C=NC3=C(NC)N=C(N)N=C32)O1)(OC4=CC=CC=C4)=O)=O
InChi Code
InChI=1S/C24H33FN7O7P/c1-13(2)37-21(34)14(3)31-40(35,39-15-9-7-6-8-10-15)36-11-16-18(33)24(4,25)22(38-16)32-12-28-17-19(27-5)29-23(26)30-20(17)32/h6-10,12-14,16,18,22,33H,11H2,1-5H3,(H,31,35)(H3,26,27,29,30)/t14-,16+,18+,22+,24+,40-/m0/s1
InChi Key
OISLSHLAXHALQZ-LZEIJKKFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    AT-511 is a prodrug form of the antiviral nucleoside analog AT-9010.1 It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Good, S.S., Westover, J., Jung, K.H., et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob. Agents Chemother. 65(4), e02479-02420 (2021).